25-12-2017

D. Shalamberidze, T.Kurashvili: Effectiveness of AAAVET 500 (Powder)

D. Shalamberidze, T.Kurashvili: Effectiveness of AAAVET 500 (Powder)
Efficiency of the drug ATAVET 500 (powder)
During bird's bacterial diseases.
David Shalamberidze
Tengiz Kurashvili
 

The emergence of any bacterial disease in the poultry farm negatively affects the epoching situation and economic conditions of farming, as the risk of bird mortality increases significantly during acute and subtleties of salmonellosis, colibacterosis, staphylococcus and other bacterial diseases.

 

In the course of the chronic disease of the bacterial diseases, the normal development of the bird is uneven and low. Increasing sensitivity to stress, decreased eggure and cutting percentage, chronic post-vaccine immunity to viral diseases, and more.

 

Effectiveness of the availability of bird bacterial diseases is greatly dependent on timely diagnosis of diseases.

 

The article describes the results of the safety and efficacy of the new, local production of ATA 500 (powder) medicinal treatment for bird bacterial diseases. Which is produced by "Draft" LLC. 1 g of powdered 500 powder (powder) contains: active substances, sulphamactazzol-400 mg; Trimethroprim - 100 mg and also auxiliary substances, starch and talc.

 

Introduction: Poultry bacterial diseases are characterized by many features and it depends primarily on the maintenance of the varieties used in industrial poultry (1).

 

Failure of compulsory zoo technology in poultry reduces bird resistance and weakens immunity. On this background there will be favorable conditions for the activation of pathogenic microflora and the development of mixed infections that complicate the diagnosis and treatment of diseases (1,2,3,4).

 

Mixed bacterial infections develop in both respiratory and gastrointestinal syndrome, since it actually involves certain groups of the same microorganisms (Eschery, Salmonell, Staphylococcus, Proteus, Pasteur, etc.). Therefore, the symptoms of diseases are general. According to statistical data mixed respiratory infections (1) are more frequent.

 

During mixed infections, there is often a decrease in the wilting of inflammatory diseases and weak development of pathogenic processes. In such a case, birds become people with toxicosinfectants (salmonolas, camphilobacterosis, etherichiosis, etc.) and are bumped into epizootological and epidemiological situations. Therefore, it is important to develop effective measures against bird bacterial diseases: one of the main activities of bird control of bacterial infections in treatment is: timely diagnosis of diseases, antibiotic prophylactics and antibiotics therapy (1,2,3,4)

 

Many antibacterial drugs are used against bird bacterial diseases. Nevertheless, research is currently underway to increase their efficiency.

 

The goal of our research was to determine the safety and efficiency of the antibacterial drug of ATA 500 (powder) of local production.

 

Objects and Methods: The 10-day 10-day chick of 35 varieties were tested for the purpose of determining the safety of the antibacterial drug ATA 500 (powder), including 5 wings of chicks representing the control group. The remaining 30 wings were divided into three groups, each in 10-10 wings, each group of chars we placed in a separate cage. The first group of trial chickens were given three times the drug, the second group of five and a third group of ten times therapeutic dose. We carried out the test and control chicks for 10 days after the preparation.

 

To determine the efficacy of the preparation, a 10-day 10-day chick of 60 wings was divided into four test groups (10-10 in each) and four control groups (5-5 in each). Take the test and control chins in the thigh muscles: the first group of salmonelles, the second group of Escherichi, the third group of staphylococcus and the fourth group of minimally deadly doses of streptococcus cultures (LD 100). Minimally deadly doses of crops were prescribed in the same age group.

 

The test chickens were given with oral water during 4 days starting from 4 hours after the introduction of the fruits. The contents of the contamination were not given to the ATA 500 (1 g in 1 l of water). The chicken nutrition and care keeping conditions were the same.

 

Results and their consideration: The study of the safety of the ATA 500 was found to indicate that in the chicken group where the triple dose of the drug was tested, the birds did not detract from the physiological norms. During the five days, the chickens were showing unease and boredom and were mobs. From the third day the birds have been exposed to these clinical signs. The above clinical signs were more pronounced and lasting when giving a tenfinal therapeutic dose. Nevertheless, during the observation period (10 days), none of the chicks died, but it was obviously signs of great stress. In fact their growth has been halted.

 

 
1879/5000
chat’arebuli tsdebis shedegad davadginet, rom ant’ibakt’eriuli p’rep’arat’i at’avet’-500 (pkhvnili) arat’oksiuri da uvnebelia, ar its’vevs ts’its’ilebis sik’vdils atmagi dozis mitsemis drosats k’i, rats gvadzlevs imis dask’vnis sashualebas, rom p’rep’arat’is gamoq’eneba usaprtkhoa.



p’rep’arat’ at’avet’ 500 -is epekt’urobis shests’avlit dadginda, rom p’irvel jgupshi, sadats ts’its’ilebi davasnebovnet salmonelis k’ult’urit, dasnebovnebidan 48 da 72 saatis shemdeg mok’vda 2 ts’its’ila. danarcheni ts’its’ilebi k’linik’urad janmrtelebi iq’vnen. ts’its’ilebis meore jgupshi, sadats prinvelebi davasnebovnet esherikhiis k’ult’urit, 72 saatis shemdeg mok’vda mkholod erti ts’its’ila. danarcheni ts’its’ilebi shedarebit akt’iurebi iq’vnen, vidre p’irveli jgupis ts’its’ilebi. mesame jgupshi (st’apilok’ok’ebis k’ult’urit dasnebovnebul ts’its’ilebshi), 48 st -is shemdeg mok’vda erti ts’its’ila. am jgupshits danarcheni prinveli janmrteli iq’o. meotkhe jgupshi, sadats ts’its’ilebi davasnebobnet st’rep’t’ok’ok’is k’ult’urit, arts erti prinveli ar momk’vdara. satsdeli otkhive jgupis mtsire nats’ili ts’its’ilebs dasnebovnebidan 24 st-is ganmavlobashi aghenishnebodat madis dakveiteba da mots’q’eniloba. mk’vdari ts’its’ilebis gak’vetisas inpektsiisatvis damakhasiatebeli nishnebi ar aghmochenila. sak’ont’rolo jgupshi q’vela ts’its’ila daikhotsa 24-48 saatis ganmavlobashi.



p’rep’arat’is epekt’urobis laborat’oriuli tsdebit dadgenis shemdeg p’rep’arat’i at’avet’-500 rek’omendebulia parto samrets’velo gamoq’enebisatvis.



dask’vna:


1. ant’ibakt’eriuli p’rep’arat’i at’avet’ 500 (pkhvnili) aris arat’oksiuri, misi terap’iuli khutmagi dozit gamoq’eneba ar its’vevs satsdel tskhovelebshi shesamchnev k’linik’ur tsvlilebebs.

2. p’rep’arat’ at’avet’ 500 -ma laborat’oriul tsdebshi gamoavlina maghali terap’iuli tvisebebi da daitsva satsdeli prinvelebi salmonelozit, esherikhiozit, st’apilok’ok’ozit da st’ep’t’ok’ok’ozit daavadebisagan.

3. p’rep’arat’is samk’urnalo-p’ropilakt’ik’uri epekt’urobis shepasebistvis autsilebelia misi samrets’velo gamoq’enebis shedegebis sts’rapi analizi.



gamoq’enebuli lit’erat’ura:
As a result of test results, we found that antibacterial drug ATA-500 (powder) is non-toxic and harmless, causing chopping death even at the time of giving a dozen doses, which gives us the conclusion that the use of the drug is safe.

 

The study of the effectiveness of the ATAVET 500 demonstrated that in the first group where the chickens were salted with Salmon's culture, 48 and 72 hours after infection were 2 chicks. The rest of the chickens were clinically healthy. In the second group of chickens where birds have been eaten by the culture of Eschery, 72 hours later, only one chicken died. The rest of the chickens were relatively active than the first group of chickens. In the third group (in chickens stewed with staphylococcus culture), one chick died after 48 hours. The rest of the birds were healthy in this group. In the fourth group where the chickens were streptococcus culture, none of the birds died. A small part of all four groups of experiments showed chances of depression and boredom during 24 hrs. The symptoms of the infection have not been detected when the dead chicks are cleared. In the control group all the chickens were killed during 24-48 hours.

 

After determining the efficacy of the preparation of the drug, the drug ATA-500 is recommended for wide industrial use.
 
 

Conclusion:


 

1. Antibacterial drug AAVEVET 500 (Powder) is non-toxic and does not use the therapeutic five-dose dose of clinical changes in the experimental animals.

2. Pharmacutal AATate 500 showed high therapeutic properties in laboratory tests and defended the test birds from salmonols, eschericosis, staphylococci and steptococcosis.

3. To evaluate the drug-preventive effectiveness of the drug, it is necessary to analyze the results of its industrial use.

 



used literature:

 

1. Борисенкова А., Животноводчество России, декабрь, 2007 15-17.

2. Конопаткин А.А. , Эпизоотология и инфекционные болезни, Москва 1993,

3. Сидорчук А.А., Воронин Е.С.  Инфекционные болезни животных, Москва 2007.

4. Филипенко М.Л., Афонюшкин В.Н., Дударева Е.В., Инфекционные заболевания сельскохозяйственной птицы-результат пересечения молекулярно – биологических особенностей возбудителя и хозяйственной деятельности человека, Инфекционные заболевания сельскохозяйственной птицы.